Salt and pepper sign (disambiguation)

Last revised by Daniel J Bell on 23 May 2022

The salt and pepper sign is used to refer to a speckled appearance of tissue on imaging. It is used in many contexts, but most commonly for the appearance of certain lesions on MRI, especially paragangliomas.

NB: pathologists also use the term "salt and pepper", to refer to a distinctive appearance of the chromatin in some diseases 10.

When you think about it, you can probably find folk who have used the term for all sorts of lesions; any lesion that has a fine granular imaging texture will do the trick.

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Cases and figures

  • Case 1: vertebral hemangioma
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  • Case 2: glomus T1 C+
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  • Case 2: glomus T2
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