Salt and pepper sign (skull)

Last revised by Dr Naim K on 21 Nov 2020

Salt and pepper sign or pepper pot skull refers to multiple tiny well-defined lucencies in the calvaria caused by resorption of trabecular bone in hyperparathyroidism. There is a loss of definition between the inner and outer tables of the skull and a ground-glass appearance as well as spotty deossification.

Occasionally, the term is used synonymously (although inaccurately) with the raindrop skull appearance of multiple lytic lesions of multiple myeloma 4.

See also

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Cases and figures

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