Citation, DOI, disclosures and article data
Citation:
Wahba M, Yap J, Bell D, et al. Non-steroidal anti-inflammatory drug exacerbated respiratory disease. Reference article, Radiopaedia.org (Accessed on 24 Apr 2024) https://doi.org/10.53347/rID-6927
Non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease refers to the clinical constellation of 1,2:
Non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease is also known as Samter syndrome (or triad), Widal syndrome, aspirin-induced asthma, aspirin exacerbated respiratory disease (AERD), and analgesic-induced asthma.
In adults, prevalence ranges between 8-20% among those given an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad 5.
Treatment and prognosis
Treatment is largely centered around avoiding aspirin, treating underlying asthma, and occasionally sinonasal polypectomy (surgical or medical). Unfortunately recurrence is common 2.
Aspirin desensitization has also been tried with at least some short term improvement 2.
History and etymology
The name Samter triad or syndrome was named after the American allergy physician Max Samter (1908-1998) 7 who was the first to comprehensively describe this clinical triad in 1968 6.
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1. Lee KJ. Essential otolaryngology, head & neck surgery. McGraw-Hill Professional. (2003) ISBN:0071373225. Read it at Google Books - Find it at Amazon
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2. Önerci TM. Nasal Polyposis, Pathogenesis, Medical and Surgical Treatment. Springer Verlag. (2010) ISBN:3642114113. Read it at Google Books - Find it at Amazon
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3. Tan JHY, Hsu AAL. Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease phenotype: Topical NSAID and asthma control - A possible oversight link. Respiratory medicine. 118: 1-3. doi:10.1016/j.rmed.2016.07.004 - Pubmed
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4. Ertoy Karagol HI, Yilmaz O, Topal E, Ceylan A, Bakirtas A. Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease in adolescents. International forum of allergy & rhinology. 5 (5): 392-8. doi:10.1002/alr.21494 - Pubmed
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5. Sih K, Goldman RD. Nonsteroidal anti-inflammatory drug administration in children with history of wheeze. Canadian family physician Medecin de famille canadien. 62 (8): 633-4. Pubmed
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6. Kim SD, Cho KS. Samter's Triad: State of the Art. (2018) Clinical and experimental otorhinolaryngology. 11 (2): 71-80. doi:10.21053/ceo.2017.01606 - Pubmed
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7. Cohen SG, Settipane GA. Max Samter, M.D. 1908-1999. (1999) Allergy and asthma proceedings. 20 (5): 329-35. doi:10.2500/108854199778251997 - Pubmed
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