SAPHO syndrome

The SAPHO syndrome is an acronym that refers to a rare condition that is manifested by a combined occurrence of 2

  • S: synovitis
  • A: acne
  • P: pustulosis 
  • H: hyperostosis
  • O: osteitis

It classically tends to present in young to middle-aged adults. Presentation in the paediatric population is not uncommon.

SAPHO and related conditions have three stages of progression, which are described as :

  1. Costoclavicular ligament ossification.
  2. Arthropathy of the sternoclavicular joint, osteitis of the medial end of the clavicle, 1st rib and sternum as well as hypertrophy of the costal cartilages.
  3. Osteitis, hyperostosis and hypertrophy of the medial ends of the clavicles, sternum and upper ribs and ultimately ankylosis.
Plain radiograph

Non-specific but can be suspected if present with the other clinical findings:

Tends to be benign although patients may have recurrent bouts of attacks. Pamidronate therapy has been successfully trialled for symptom relief (especially in the paediatric population 6).

Chamot et al. initially described it in 1987 3.

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Article Information

rID: 8415
Section: Syndromes
Tag: cases
Synonyms or Alternate Spellings:
  • SAPHO
  • Synovitis acne pustulosis hyperostosis osteitis

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