Sarcoidosis (cardiac manifestations)

Cardiac manifestations of sarcoidosis are present in up to 25% of patients with sarcoidosis, but only 5-10% of patients are symptomatic 1-2.

Sarcoidosis is a multisystem disorder characterised by the presence of non-caseating granulomas. For a general discussion of this condition please refer to the main sarcoidosis article. 

Over half of patients with autopsy-proven cardiac involvement are asymptomatic. Symptoms include 1,4:

  • arrhythmias including sudden death (most common) and heart block
  • congestive cardiac failure
  • angina pectoris (i.e. chest pain), palpitations and syncope
  • ventricular aneurysm formation

Although the involvement of the pericardium is rare, constrictive pericarditis has been described 1.

Cardiac sarcoidosis is an inflammatory process that results in scarring, most commonly of the interventricular septum, posterior left ventricle, right ventricle, and anterior left ventricle 4. Cardiomegaly is often frequently present 4

Although the disease may involve either the left or the right ventricle, the left ventricle is involved most commonly.

  • rarely seen on CT; myocardial thinning may be the only sign 3 although extra-cardiac thoracic manifestations may be present (i.e. pulmonary changes, lymphadenopathy)
  • cardiomegaly, pericardial effusions and ventricular aneurysms may also be present 4

The modality of choice. Common MRI findings in patients with cardiac sarcoid include:

  • delayed enhancement, which may be either mid-wall or transmural
  • nodular mid-wall hyperintense foci on black blood T2-weighted imaging
  • areas of focal myocardial thickening

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Article Information

rID: 9146
System: Cardiac
Section: Pathology
Synonyms or Alternate Spellings:
  • Cardiac sarcoidosis
  • Sarcoidosis of the heart

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