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Schneiderian papillomas account for ~2.5% (range 0.4-4.7%) of sinonasal tumors 2.
There are three distinct histological types 1-4:
- inverted papilloma (most common, ~50-80%)
- exophytic papilloma (~20-50%): synonyms and superseded subtypes include transitional cell papilloma, fungiform papilloma, squamous papilloma, Ringertz tumor, and everted papilloma
- oncocytic papilloma (~5%): superseded subtypes include cylindrical cell papilloma and columnar cell papilloma
Schneiderian papillomas appear as abnormal soft tissue within the nasal cavity and/or paranasal sinuses. Inverted and oncocytic papillomas usually arise from the lateral nasal wall or paranasal sinuses (usually maxillary or ethmoid). Exophytic papillomas usually arise from the lower anterior nasal septum. With more extensive disease, there may be paranasal sinus opacification and bony structure expansion or even pressure erosion.
Treatment and prognosis
The inverted and oncocytic types of Schneiderian papilloma carry a 5-15% risk of malignant transformation to carcinoma (most commonly squamous cell carcinoma, but other types have been described as well). The exophytic papilloma type has essentially no malignant potential.
History and etymology
It is named after the Schneiderian epithelium, which itself was named for Conrad Victor Schneider (1614-1680), a German anatomist and physician from Wittenberg, Germany 4,6.
- 1. Vorasubin N, Vira D, Suh JD et-al. Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types. Am J Rhinol Allergy. 2013;27 (4): 287-92. doi:10.2500/ajra.2013.27.3904 - Free text at pubmed - Pubmed citation
- 2. Barnes, Leon. "Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck." Modern pathology 15.3 (2002): 279-297.
- 3. Wieneke JA, Koeller KK. Head neck pathol radiology pathology classics. Head Neck Pathol. 2007;1 (2): 99-101. doi:10.1007/s12105-007-0019-0 - Free text at pubmed - Pubmed citation
- 4. William Alexander Newman Dorland. Dorland's Illustrated Medical Dictionary. (2018) ISBN: 9781416023647
- 5. Leon Barnes, World Health Organization, International Agency for Research on Cancer. Chapter 1: Tumours of the Nasal Cavity and Paranasal Sinuses. Pathology and Genetics of Head and Neck Tumours. (2019) ISBN: 9789283224174
- 6. Bosmia A, Shane Tubbs R. Conrad Victor Schneider (1610/1614 - 1680): Physician and Anatomist Who Described the Sinonasal Mucosa. International Journal of the History and Philosophy of Medicine (2013) 3:12-15.