Schwannomas are benign tumours of Schwann cell origin and are the most common tumour of peripheral nerves, and common posterior fossa masses. 

This article provides a general overview of schwannomas. For a discussion of schwannomas located at specific sites, please refer to the relevant articles listed below.

Peak presentation is in the 5th-6th decades. When they occur in patients with neurofibromatosis type 2 (NF2), schwannomas usually present by the 3rd decade 4. There is no sex predilection.

Most schwannomas are solitary (90%) 2 and sporadic, however, there is an association with NF2 (abnormality of chromosome 22). Multiple schwannomas are characteristic of NF2. Approximately 18% of solitary schwannomas occur in patients with NF2 4.

There is also schwannomatosis, which consists of multiple schwannomas without the concomitant involvement of cranial nerve VIII.

Presentation depends on the location of the tumour (see below) but generally, symptoms are due to local mass effect or dysfunction of the nerve they arise from. 

Schwannomas are benign encapsulated neoplasms of Schwann cells (WHO grade I). They arise eccentrically from their parent nerve, with the nerve fibres splayed along their surface (as distinct to neurofibromas which arise within the nerve).

Conventional schwannomas are composed of spindle cells which demonstrate two growth patterns: Antoni type A and Antoni type B 7,8.

Antoni type A pattern: elongated cells are densely packed and arranged in fascicles. Palisades are sometimes seen; when prominent these form Verocay bodies.

Antoni type B pattern cells are less compact and are prone to cystic degeneration.

Schwannoma variants include 6,8:

  • ancient schwannoma
  • cellular schwannoma
    • predominantly composed of Antoni A tissue
    • no Verocay bodies
    • most commonly found in a paravertebral location, or trigeminal nerves (CN V)
  • melanotic schwannoma: dense melanin pigment
  • plexiform schwannoma
    • usually arise from skin or subcutaneous tissues
    • usually diagnosed at birth or childhood
    • usually sporadic, but rarely associated with NF2
    • should not be confused with plexiform neurofibromas
      • associated with NF1
      • may undergo malignant change

General imaging features of schwannomas include:

  • well circumscribed masses which displace adjacent structures without direct invasion
  • cystic and fatty degeneration are common 4
  • the larger a schwannoma, the more likely it is to show heterogeneity because of cystic degeneration or haemorrhage 3
  • haemorrhage occurs in 5% of cases 3
  • calcification is rare

CT is not as sensitive or specific for the diagnosis of schwannoma as MRI but is often the first investigation obtained. It is particularly useful in assessing bony changes adjacent to the tumour. 

Imaging features include: 

  • low to intermediate attenuation
  • intense contrast enhancement
    • small tumours typically demonstrate homogeneous enhancement
    • larger tumours may show heterogeneous enhancement
  • adjacent bone remodelling with smooth corticated edges

Schwannomas have fairly predictable signal characteristics 7:

  • T1: isointense or hypointense
  • T1 C+ (Gd): intense enhancement
  • T2: heterogeneously hyperintense (Antoni A: relatively low, Antoni B: high)
    • cystic degenerative areas may be present, especially in larger tumours
  • T2*: larger tumours often have areas of hemosiderin

A number of signs can also be useful:

  • split-fat sign: thin peripheral rim of fat best seen on planes along long axis of the lesion in non-fat-suppressed sequences
  • target sign
    • peripheral high T2 signal
    • central low signal
    • rarely seen intracranially 7
  • fascicular sign: multiple small ring-like structures

Schwannomas are slow-growing lesions. Surgery is the treatment of choice. As schwannomas do not infiltrate the parent nerve, they can usually be separated from it. Recurrence is unusual, even after complete resection. They almost never undergo malignant change.

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Article information

rID: 19575
Synonyms or Alternate Spellings:
  • Schwannomas
  • Schwannoma - general

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Cases and figures

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    Case 1: spinal schwannoma
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    Case 2: bilateral vestibular schwannomas - NF2
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    Case 3: brachial plexus
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    Case 4: oculomotor nerve
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    Case 5: jugular foramen
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    Case 6: glossopharyngeal nerve schwannoma
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    Case 7: T2
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    Case 8: vestibular schwannoma
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    Case 9: pelvic schwannoma
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    Case 10: parapharyngeal space schwannoma
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    Case 11: spinal schwannoma
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    Case 12: Schwannoma of the neck
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    Case 13: abdominal schwannomas
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    Case 14: vagus nerve
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