Sclerosing lobular hyperplasia of breast

Sclerosing lobular hyperplasia (SLH) of the breast, also known as fibro-adenomatoid mastopathy, is an uncommon benign proliferative breast lesion.

It tends to occur more often in adolescent and young adult patients (peak age in the thirties). In the United States, there may be a greater incidence in African American women 2

It often presents as a circumscribed mass and may or may not be palpable. 

It is histologically characterised by enlarged lobules (with prominent lobular hyperplasia) an increased number of intralobular ductules and sclerosis of the intralobular connective tissue.

  • fibroadenoma: a fibroadenoma can have surrounding SLH in ~ 50% of cases 7

May present as a rounded radiodensity of variable size (1-8 cm 6) and may resemble a non-calcified fibroadenoma. 

Has a nonspecific sonographic appearance and may be seen as a lobular or oval-shaped mass with a circumscribed margin 5.

General differential considerations include

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Article information

rID: 13650
System: Breast
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Sclerosing lobular hyperplasia of the breast
  • Fibroadenomatoid mastopathy
  • SLH breast
  • Mammary sclerosing lobular hyperplasia
  • Sclerosing lobular hyperplasia

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