Sclerosing mesenteritis (or mesenteric panniculitis) is an uncommon idiopathic disorder characterised by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery.
Typically this condition afflicts adults in their sixties with mild male predilection, although reports vary 1,2,4.
Clinical presentation can be variable with abdominal pain, intestinal obstruction or ischaemia, a mass, or diarrhoea. Altered bowel habits, and weight loss may be present in some cases. Occasionally, intermittent partial bowel obstruction is encountered 2. A firm left upper quadrant / central abdominal mass may be felt 2. In some situations sclerosing mesenteritis is asymptomatic.
The disease is said to pass through three stages, although some authors believe these to be separate entities 4:
- mesenteric lipodystrophy: degeneration of mesenteric fat
- mesenteric panniculitis: inflammatory reaction
- retractile mesenteritis / sclerosing mesenteritis: fibrosis, which may be associated with distortion or lymphatic obstruction
Macroscopically, the mesentery is thickened with either solitary or multiple focal masses 4.
Histology demonstrates 1:
- lipid-laden macrophages (mesenteric lipodystrophy)
- lymphocytic aggregates and lymphoid follicles (mesenteric panniculitis)
- variable amounts of fibrosis (retractile mesenteritis)
Numerous associated conditions have been variably described including 1,4:
- recent abdominal surgery 4
- systemic inflammatory conditions
- autoimmune conditions (may be related to IgG4-related disease)
- may be related to Weber-Christian disease 2
There is debate about the association between systemic inflammatory conditions and mesenteric panniculitis. Determining causation is difficult. The term "secondary mesenteric panniculitis" is reserved by some authors for patients with systemic inflammatory conditions. Most authors would not use the term when there is a local cause for mesenteric inflammation.
Ultrasound typically demonstrates distortion and thickening of the root of the mesentery with a slight decrease in echogenicity. Mass effect may be evident 3. A halo of sparing around vessels may be also seen on ultrasound as a region of hyperechoic fat 3. Colour Doppler interrogation may show non-deviated mesenteric vessels within the mass 17.
CT features are somewhat dependent on the main tissue component and include:
- well-demarcated or ill-defined mesenteric masslike lesion with surrounding "misty" attenuation
- "misty" soft-tissue attenuation
The mesentery demonstrates mass effect and may have a ground glass opacity (misty mesentery). Typically the traversing mesenteric vessels and soft tissue nodules have a spared fat halo (this has sometimes been referred to as the fat ring sign). Its orientation is aligned with the root of the jejunal mesentery. Punctate/coarse calcifications (~20%) as well as small lymph nodes (usually <5 mm) may be present within the region.
Findings are similar to CT. One report described a fibrous capsule around the inflammation 12.
May have high accuracy for the differentiation between
- sclerosing mesenteritis (or one of its stages): not FDG-avid
- malignant mesenteric involvement: FDG-avid
especially in patients with lymphoma 10. If in doubt, biopsy may be indicated in selected patients, even in asymptomatic lesions 11.
Treatment and prognosis
The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated 2. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit. In up to 15% of cases, local lymphoma eventually develops 2, 4. Some authors suggest associated malignancy rate of approximately 56% 16.
History and etymology
It was first described by Jura in 1924 as “retractile mesenteritis” and further labelled as “mesenteric panniculitis” by Odgen later in the 1960s.
General imaging differential considerations include:
- mesenteric lymphadenopathy due to malignancy:
- mesenteric lymphadenopathy due to inflammation:
- mesenteric lipoma: especially if large and if there are lymph nodes within it
- intraperitoneal focal fat infarction
- 1. Daskalogiannaki M, Voloudaki A, Prassopoulos P et-al. CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol. 2000;174 (2): 427-31. AJR Am J Roentgenol (full text) - Pubmed citation
- 2. Doherty GM, Way LW. Current surgical diagnosis & treatment. McGraw-Hill Medical. (2006) ISBN:007142315X. Read it at Google Books - Find it at Amazon
- 3. Herlinger H, Maglinte DD, Birnbaum BA et-al. Clinical Imaging of the Small Intestine. Springer Verlag. (2001) ISBN:0387953884. Read it at Google Books - Find it at Amazon
- 4. Patel N, Saleeb SF, Teplick SK. General case of the day. Mesenteric panniculitis with extensive inflammatory involvement of the peritoneum and intraperitoneal structures. Radiographics. 19 (4): 1083-5. Radiographics (full text) - Pubmed citation
- 5. Jeong YJ, Kim S, Kwak SW et-al. Neoplastic and nonneoplastic conditions of serosal membrane origin: CT findings. Radiographics. 28 (3): 801-17. doi:10.1148/rg.283075082 - Pubmed citation
- 6. Lucey BC, Stuhlfaut JW, Soto JA. Mesenteric lymph nodes seen at imaging: causes and significance. Radiographics. 25 (2): 351-65. doi:10.1148/rg.252045108 - Pubmed citation
- 7. Coulier B. Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study. JBR-BTR. 2012;94 (5): 241-6. Pubmed citation
- 8. Coulier B. Mesenteric panniculitis. Part 1: MDCT-pictorial review. JBR-BTR. 2012;94 (5): 229-40. Pubmed citation
- 9. Issa I, Baydoun H. Mesenteric panniculitis: various presentations and treatment regimens. World J. Gastroenterol. 2009;15 (30): 3827-30. Free text at pubmed - Pubmed citation
- 10. Zissin R, Metser U, Hain D et-al. Mesenteric panniculitis in oncologic patients: PET-CT findings. Br J Radiol. 2006;79 (937): 37-43. doi:10.1259/bjr/29320216 - Pubmed citation
- 11. Tamai Y et. al. A case of follicular lymphoma complicated with mesenteric panniculitis, Hematol Rev. Jul 1, 2009; 1(2): e17.
- 12. Ghanem N, Pache G, Bley T et-al. MR findings in a rare case of sclerosing mesenteritis of the mesocolon. J Magn Reson Imaging. 2005;21 (5): 632-6. doi:10.1002/jmri.20280 - Pubmed citation
- 13. Seo BK, Ha HK, Kim AY, Kim TK, Kim MJ, Byun JH, Kim PN, Lee MG, Yang SK, Yu ES, Kim JH. Segmental misty mesentery: analysis of CT features and primary causes. Radiology. 226 (1): 86-94. doi:10.1148/radiol.2261011547 - Pubmed
- 14. Horton KM, Lawler LP, Fishman EK. CT findings in sclerosing mesenteritis (panniculitis): spectrum of disease. Radiographics : a review publication of the Radiological Society of North America, Inc. 23 (6): 1561-7. doi:10.1148/rg.1103035010 - Pubmed
- 15. van Putte-Katier N, van Bommel EF, Elgersma OE, Hendriksz TR. Mesenteric panniculitis: prevalence, clinicoradiological presentation and 5-year follow-up. The British journal of radiology. 87 (1044): 20140451. doi:10.1259/bjr.20140451 - Pubmed
- 16. Badet N, Sailley N, Briquez C, Paquette B, Vuitton L, Delabrousse É. Mesenteric panniculitis: still an ambiguous condition. Diagnostic and interventional imaging. 96 (3): 251-7. doi:10.1016/j.diii.2014.12.002 - Pubmed
- 17. Rosón N, Garriga V, Cuadrado M, Pruna X, Carbó S, Vizcaya S, Peralta A, Martinez M, Zarcero M, Medrano S. Sonographic findings of mesenteric panniculitis: correlation with CT and literature review. Journal of clinical ultrasound : JCU. 34 (4): 169-76. doi:10.1002/jcu.20214 - Pubmed
- 18. Sato M, Ishida H, Konno K, Komatsuda T, Naganuma H, Watanabe S, Ohyama Y, Itoh M, Mukojima T, Sakai T. Mesenteric panniculitis: sonographic findings. Abdominal imaging. 25 (2): 142-5. Pubmed