Second-impact syndrome

Second-impact syndrome (SIS) is a rare traumatic brain injury occurs in athletes receiving a second head injury while still symptomatic from a prior head injury.

Second-impact syndrome is common in young athletes.

The typical second-impact syndrome scenario occurs usually when an athlete sustains an initial head injury with post concussion symptoms such as headache, dizziness and vertigo, then he suffers a second head injury before the symptoms associated with the first impact have cleared.

The athlete during the second head injury precipitously lapses into coma with signs of brain herniation. 

The pathophysiology of second-impact syndrome is poorly understood, However It's presumed to be secondary to loss of autoregulation of the cerebrovasculature which leads to hypermic brain swelling which in turn increases intracranial pressure, brain herniation and death.

Following an initial insult there's characteristic ionic fluxes, acute metabolic changes, and cerebral blood flow alterations that occur immediately after cerebral concussions. Extracellular potassium concentration can increase massively in the brain, followed by hypermetabolism which can last up to ten days. This makes the brain more vulnerable and susceptible to death after a second sub-lethal insult of even less intensity.

CT and MRI can demonstrate the cerebral hyperaemic swelling, brain herniation and post-herniation ischemia.

Intracranial (thin subdural haemorrhage) may be seen yet with severe midline shift and mass effect that appear disproportionate to the size of the haematoma

The treatment usually indicates decompressive craniectomy and evacuation of the SDH.

The use of mannitol in the treatment of intracranial pressure (ICP).

Any athlete who shows signs of concussion should not resume playing with appropriate outpatient follow up by a neurosurgeon. 

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Article Information

rID: 53228
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • DSIS
  • Dysautoregulation second impact syndrome
  • Second-impact-syndrome
  • Second-impact syndrome (SIS)

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