Secondary involvement of the bone with lymphoma

Dr Tim Luijkx and Dr Henry Knipe et al.

Secondary involvement of the bone with lymphoma, also referred as secondary bone lymphoma, is much more common than primary bone lymphoma, occurring in ~15% of disseminated lymphomas.

Secondary bone lymphoma is defined as lymphoma involving the bone with nodal disease occurring within six months or secondary lymphoma involving the bone at least six months after diagnosis.

Secondary bone involvement is more common in children (25%) 1

Bone pain and/or pathological fracture

Secondary bone involvement can result from direct spread from nodal disease or haematogenous metastases. The axial skeleton is more often affected than the appendicular skeleton 2. The most frequent locations are 1,3:

  • lytic lesion(s)
  • permeative bone destruction with cortical breach
  • adjacent soft tissue mass(es)
Bone tumours

The differential diagnosis for bone tumours is dependent on the age of the patient, with a very different set of differentials for the paediatric patient.

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Article information

rID: 33195
Synonyms or Alternate Spellings:
  • Secondary bone lymphomas (SBL)
  • Secondary osseous lymphomas
  • Secondary skeletal lymphomas

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