Secondary involvement of the bone with lymphoma
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At the time the article was created Henry Knipe had no recorded disclosures.
View Henry Knipe's current disclosuresAt the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures- Secondary osseous lymphomas
- Secondary skeletal lymphomas
- Secondary bone lymphomas (SBL)
Secondary involvement of the bone with lymphoma, also referred as secondary bone lymphoma, is much more common than primary bone lymphoma, occurring in ~15% of disseminated lymphomas.
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Terminology
Secondary bone lymphoma is defined as lymphoma involving the bone with nodal disease occurring within six months or secondary lymphoma involving the bone at least six months after diagnosis.
Epidemiology
Secondary bone involvement is more common in children (25%) 1.
Clinical presentation
Bone pain and/or pathological fracture
Pathology
Secondary bone involvement can result from direct spread from nodal disease or hematogenous metastases. The axial skeleton is more often affected than the appendicular skeleton 2. The most frequent locations are 1,3:
- spine
- bony pelvis
- skull
- ribs
- facial bones
Radiographic features
Plain radiograph / CT
- lytic lesion(s)
- permeative bone destruction with cortical breach
- adjacent soft tissue mass(es)
References
- 1. Malloy PC, Fishman EK, Magid D. Lymphoma of bone, muscle, and skin: CT findings. AJR Am J Roentgenol. 1992;159 (4): 805-9. doi:10.2214/ajr.159.4.1529847 - Pubmed citation
- 2. Ferry JA. Extranodal Lymphomas. Saunders. ISBN:1416045791. Read it at Google Books - Find it at Amazon
- 3. Lim CY, Ong KO. Imaging of musculoskeletal lymphoma. Cancer Imaging. 2013;13 (4): 448-57. doi:10.1102/1470-7330.2013.0036 - Free text at pubmed - Pubmed citation
- 4. Wu H, Bui MM, Leston DG et-al. Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 2014;14 (1): 900. doi:10.1186/1471-2407-14-900 - Free text at pubmed - Pubmed citation
- 5. Feller AC, Diebold J, Lennert K. Histopathology of Non-Hodgkin's Lymphomas. Springer. ISBN:3540638016. Read it at Google Books - Find it at Amazon
- 6. Stroszczynski C, Oellinger J, Hosten N et-al. Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI. J. Nucl. Med. 1999;40 (3): 387-93. Pubmed citation
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