Secondary organizing pneumonia

Last revised by Daniel J Bell on 21 Jun 2021

Secondary organizing pneumonia (SOP) refers to organizing pneumonia that can be attributed to a specific cause, in contrast to cryptogenic organizing pneumonia (COP) in which no cause is present. 



Secondary organizing pneumonia can be attributed to the following causes 1:

Prior infection
  • antimicrobials
    • amphotericin B, cephalosporins, nitrofurantoin, minocycline
  • chemotherapeutics
    • bleomycin, busulfan, chlorambucil, doxorubicin, trastuzumab
  • interferons
  • methotrexate
  • amiodarone
  • phenytoin

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