Sepsis associated encephalopathy

Dr Tim Luijkx and Dr Bruno Di Muzio et al.

Sepsis-associated encephalopathy (SAE) is a clinical term used to express a diffuse brain dysfunction, from mild delirium to deep coma, occurring secondary to a sepsis without overt central nervous system infection. It usually occurs in critically ill patients in intensive care units, especially in those with severe systemic infection 1-3.


Sepsis-associated encephalopathy must be differentiated from septic-embolic encephalitis, which refers to a focal or diffuse brain infection, ischaemic and haemorrhagic damages following an infective thromboembolism from any part of the body. 

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Article information

rID: 36857
Synonyms or Alternate Spellings:
  • Sepsis-associated encephalopathy (SAE)

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