Sepsis-associated encephalopathy (SAE) is a clinical term used to express a diffuse brain dysfunction, from mild delirium to deep coma, occurring secondary to a sepsis without overt central nervous system infection. It usually occurs in critically ill patients in intensive care units, especially in those with severe systemic infection 1-3.
Sepsis-associated encephalopathy must be differentiated from septic-embolic encephalitis, which refers to a focal or diffuse brain infection, ischaemic and haemorrhagic damages following an infective thromboembolism from any part of the body.
- 1. Gofton TE, Young GB. Sepsis-associated encephalopathy. Nat Rev Neurol. 2012;8 (10): 557-66. doi:10.1038/nrneurol.2012.183 - Pubmed citation
- 2. Chaudhry N, Duggal A. Sepsis Associated Encephalopathy. Advances in Medicine. 30;2014: . doi:10.1155/2014/762320
- 3. Zhang QH, Sheng ZY, Yao YM. Septic encephalopathy: when cytokines interact with acetylcholine in the brain. Mil Med Res. 2014;1 (1): 20. doi:10.1186/2054-9369-1-20 - Free text at pubmed - Pubmed citation