Sepsis
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Sepsis is a syndrome, with a poorly understood pathogenesis, characterised clinically by a recognised set of signs and symptoms in someone with presumed infection.
Terminology
Sepsis was defined by The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) in 2016 as "life-threatening organ dysfunction caused by a dysregulated host response to infection" 1.
Septic shockforms a subpopulation of the sepsis cohort, manifesting as synchronous severe cardiovascular, cellular and metabolic dysfunctions, linked to an elevated risk of mortality, compared toversus sepsis alone 1.
Establishing the diagnosis of septic shock in adult patients requires that following satisfactory fluid resuscitation there is:
- hypotension, necessitating pressors to achieve an average blood pressure of greater than or equal to 65 mmHg, coupled with
- serum lactate >2 mmol/L
-<p><strong>Sepsis</strong> is a <a title="Syndrome (definition)" href="/articles/syndrome-definition">syndrome</a>, with a poorly understood pathogenesis, characterised clinically by a recognised set of signs and symptoms in someone with presumed infection.</p><h4>Terminology</h4><p>Sepsis was defined by The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) in 2016 as "life-threatening organ dysfunction caused by a dysregulated host response to infection" <sup>1</sup>. </p><p><a title="Septic shock" href="/articles/septic-shock">Septic shock</a><strong> </strong>forms a subpopulation of the sepsis cohort, manifesting as synchronous severe cardiovascular, cellular and metabolic dysfunctions, linked to an elevated risk of mortality, compared to sepsis alone <sup>1</sup>.</p>- +<p><strong>Sepsis</strong> is a <a href="/articles/syndrome-definition">syndrome</a>, with a poorly understood pathogenesis, characterised clinically by a recognised set of signs and symptoms in someone with presumed infection.</p><h4>Terminology</h4><p>Sepsis was defined by The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) in 2016 as "life-threatening organ dysfunction caused by a dysregulated host response to infection" <sup>1</sup>. </p><p><strong>Septic shock </strong>forms a subpopulation of the sepsis cohort, manifesting as synchronous severe cardiovascular, cellular and metabolic dysfunctions, linked to an elevated risk of mortality, versus sepsis alone <sup>1</sup>.</p><p>Establishing the diagnosis of septic shock in adult patients requires that following satisfactory fluid resuscitation there is:</p><ul>
- +<li>hypotension, necessitating pressors to achieve an average blood pressure of greater than or equal to 65 mmHg, coupled with</li>
- +<li>serum lactate >2 mmol/L</li>
- +</ul><p> </p>
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