Sequential Organ Failure Assessment score
Citation, DOI, disclosures and article data
At the time the article was created Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
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The Sequential Organ Failure Assessment (SOFA) score (originally called the Sepsis-related Organ Failure Assessment (SOFA) score) was developed as a clinical scoring system to provide an overview of where any critically ill patient was with regards to the sequence of organ system failure. It was not explicitly designed/intended to be a prognostic score, although later research has established that it can be used as such 1,2.
Each of six organ systems is independently assigned a score of 1 to 4. The total SOFA score represents a summation of these six scores, with scores ranging 6 to 24, with sicker patients generally being assigned higher scores 1,2.
Depending on the value of each parameter, a score from 1-4 can be assigned for each organ system:
- respiration: PaO2
- coagulation: platelets
- liver: bilirubin
- cardiovascular: hypotension
- CNS: Glasgow Coma Scale (GCS)
- renal: creatinine or urine output
History and etymology
The European Society of Intensive Care Medicine (ESICM) devised the sequential organ failure assessment score at a consensus meeting in October 1994 in Paris, France 1.
- 1. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. (1996) Intensive care medicine. 22 (7): 707-10. doi:10.1007/bf01709751 - Pubmed
- 2. Jones AE, Trzeciak S, Kline JA. The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. (2009) Critical care medicine. 37 (5): 1649-54. doi:10.1097/CCM.0b013e31819def97 - Pubmed