Citation, DOI, disclosures and article data
Citation:
Yap J, Glick Y, Murphy A, et al. Serous carcinoma of the endometrium. Reference article, Radiopaedia.org (Accessed on 14 Jan 2025) https://doi.org/10.53347/rID-17253
Serous carcinoma of the endometrium is an uncommon histological subtype of endometrial carcinoma accounting for only 5-10% of all such tumors 2. It is has a clinically aggressive form with early extension of the tumor via fallopian tubes into the peritoneum and peritoneal seeding. This accounts for its poorer prognosis compared to the other adenocarcinomas of the uterus. This is thought to closely resemble ovarian serous carcinoma 1.
Pathology
Like is ovarian counterpart, it is characterized by glandular growth patterns and/or papillary projections, and frequently contains psammoma bodies (may be found in a third of cases) that may calcify 2.
Markers
This subtype may increase serum CA-125 levels 2.
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1. Hendrickson M, Ross J, Eifel P et-al. Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma. Am. J. Surg. Pathol. 1982;6 (2): 93-108. - Pubmed citation
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2. Van mieghem IM, Gryspeerdt S, Baekelandt M et-al. Papillary serous adenocarcinoma of the endometrium: CT-pathologic correlation. AJR Am J Roentgenol. 2004;182 (6): 1534-6. AJR Am J Roentgenol (full text) - Pubmed citation
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3. Carcangiu ML, Chambers JT. Uterine papillary serous carcinoma: a study on 108 cases with emphasis on the prognostic significance of associated endometrioid carcinoma, absence of invasion, and concomitant ovarian carcinoma. Gynecol. Oncol. 1992;47 (3): 298-305. - Pubmed citation
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4. FRCPath VKMBBSMD, MBBS AKA, Aster JC. Robbins Basic Pathology. Saunders. (2012) ISBN:1437717810. Read it at Google Books - Find it at Amazon
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