Serrated polyposis syndrome
Serrated polyposis syndrome (SPS), also called hyperplastic polyposis syndrome, is characterised by the presence of multiple serrated polyps or a mixture of serrated and hyperplastic polyps, with the exact number required for diagnosis dependent on location and family history.
SPS has an heterogeneous genetic underpinning with BRAF and KRAS mutations being the most common, with an incidence of ~70%. Colorectal carcinoma may develop in up to 50% of patients.
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