Serrated polyposis syndrome (SPS), also called hyperplastic polyposis syndrome, is one of numerous polyposis syndromes and is characterized by the presence of multiple serrated polyps or a mixture of serrated and hyperplastic polyps, with the exact number required for diagnosis dependent on location and family history.
Serrated polyposis syndrome has a heterogeneous genetic underpinning with BRAF and KRAS mutations being the most common, with an incidence of ~70%. Colorectal carcinoma may develop in up to 50% of patients.