Sertoli cell tumour of the testis
May present in both paediatric and adult males, depending on the histologic subtype.
Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia.
Can occur in four histologic types:
- large-cell calcifying (paediatric)
- intratubular large cell hyalinizing Sertoli cell neoplasia (LCCSCT)
- associated with paediatric males with Peutz-Jegher syndrome
- sclerosing Sertoli cell tumor (adults)
- Sertoli cell, not otherwise specified
Sertoli cell tumours are less likely to be hormonally active (aromatase) than Leydig cell tumours.
Sertoli cell tumours of the testis are associated with the Carney complex.
- ill-defined hypoechoic intratesticular lesion
- usually solitary, unless part of a syndrome
- large cell subtype may present with multiple and bilateral mass with large areas of calcification
- limited characterization in the literature, nonspecific appearance
- T2: homogeneously hypointense
- T1 C+ (Gd): homogeneous enhancement
Treatment and prognosis
Unfortunately, although most are benign, the ultrasound appearance overlaps with malignancy, and the majority are diagnosed after orchiectomy.
There are a few case reports of malignant Sertoli cell tumours, but the majority appear benign. There are no known cases of malignant LCCSCT 2, but data is limited.
Ultrasound - testicular and scrotal
- ultrasound (introduction)
testicular and scrotal ultrasound
unilateral testicular lesion
- testicular torsion
- testicular rupture
- germ cell tumours of the testis
- sex cord / stromal tumours of the testis
- bilateral testicular lesion
- paratesticular lesions
- tubular ectasia of the rete testis
- cystadenoma of the rete testis
- testicular sarcoidosis
- testicular tuberculosis
- spermatic cord
- fibrous pseudotumour of the scrotum
- scrotal leiomyosarcoma
- testicular adrenal rest tumours (TARTs)
- tunica vaginalis testis mesothelioma
- splenogonadal fusion
- unilateral testicular lesion
- 1. Sommers D, Winter T. Ultrasonography Evaluation of Scrotal Masses. Radiol. Clin. North Am. 2014;52 (6): 1265-1281. doi:10.1016/j.rcl.2014.07.014 - Pubmed citation
- 2. Ulbright TM, Young RH. Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades. Semin Diagn Pathol. 2014;31 (5): 323-81. doi:10.1053/j.semdp.2014.07.003 - Pubmed citation
- 3. Chung EM, Biko DM, Schroeder JW et-al. From the radiologic pathology archives: precocious puberty: radiologic-pathologic correlation. Radiographics. 2012;32 (7): 2071-99. doi:10.1148/rg.327125146 - Pubmed citation
- 4. Woodward PJ, Sohaey R, O'Donoghue MJ et-al. From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation. Radiographics. 2002;22 (1): 189-216. doi:10.1148/radiographics.22.1.g02ja14189 - Pubmed citation
- 5. Tanaka U, Kitajima K, Fujisawa M et-al. Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. Jpn J Radiol. 2013;31 (4): 286-8. doi:10.1007/s11604-012-0177-1 - Pubmed citation