Sertoli cell tumour of the testis

Sertoli cell tumours of the testis are uncommon sex cord stromal tumours. They are less common than Leydig cell tumours of the testis

May present in both paediatric and adult males, depending on the histologic subtype.

Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia.

Can occur in four histologic types:

  • large-cell calcifying (paediatric)
  • intratubular large cell hyalinizing Sertoli cell neoplasia (LCCSCT)
  • sclerosing Sertoli cell tumor (adults)
  • Sertoli cell, not otherwise specified

Sertoli cell tumours are less likely to be hormonally active (aromatase) than Leydig cell tumours.

Sertoli cell tumours of the testis are associated with the Carney complex.

Ultrasound
  • ill-defined hypoechoic intratesticular lesion
  • usually solitary, unless part of a syndrome
    • large cell subtype may present with multiple and bilateral mass with large areas of calcification
MRI
  • limited characterization in the literature, nonspecific appearance
  • T2: ​homogeneously hypointense
  • T1 C+ (Gd)​: homogeneous enhancement

Unfortunately, although most are benign, the ultrasound appearance overlaps with malignancy, and the majority are diagnosed after orchiectomy.

There are a few case reports of malignant Sertoli cell tumours, but the majority appear benign. There are no known cases of malignant LCCSCT 2, but data is limited.

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Article information

rID: 33486
System: Urogenital
Synonyms or Alternate Spellings:
  • Testicular Sertoli cell tumour
  • Testicular Sertoli cell tumor

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