Shading sign (endometrioma)

Last revised by Dr Mostafa El-Feky on 07 Sep 2022

Shading sign is an MRI finding typically seen in an endometrioma. It may also be seen with some endometrioid tumors (e.g endometrioid carcinoma of the ovary) and uncommonly other blood-containing lesions (e.g. hemorrhagic corpus luteum cysts).

The sign is seen on T2-weighted sequences of lesions that are hyperintense on T1, and consists of low signal (T2 shortening) affecting variable portions of the cyst. It may involve only a small portion of the cysts, typically layering dependently. Alternatively, it may involve the entire cyst. The signal is due to the high concentration of protein and iron within the endometrioma from recurrent hemorrhage. The degree of shading can vary from faint to complete signal loss.

There are different patterns of appearance 3:

  • homogenous shading: the most prevalent pattern in endometriomas
  • heterogeneous shading: the most specific for endometriomas
  • layering: the lower layers are darker
  • liquid–liquid level: the least common
  • focal/multifocal shading within a complex mass: unlikely for endometriomas

Marked loss of signal intensity on T2-weighted images is not usually seen with hemorrhagic cysts, since they do not repeatedly bleed. Without recurrent hemorrhage and concentration of contents, the viscosity of the cyst remains lower, and shading is not present or less dark 1.

When noted with endometriosis, lesions demonstrating a shading sign may be less likely to respond to medical treatment 2.

History and etymology

It was first described by Nishimura and his team in 1987 4.

See also

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: T2
    Drag here to reorder.
  • Case 2: T2
    Drag here to reorder.
  • Case 3: T2
    Drag here to reorder.
  • Case 4: T2
    Drag here to reorder.
  • Case 5: T2
    Drag here to reorder.
  • Case 6
    Drag here to reorder.
  • Case 7
    Drag here to reorder.
  • Case 8
    Drag here to reorder.
  • Case 9
    Drag here to reorder.
  • Case 10
    Drag here to reorder.
  • Case 11
    Drag here to reorder.
  • Case 12
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.