Sheehan syndrome is a rare cause of pituitary apoplexy and hypopituitarism.
It only occurs in postpartum females who experience large volume haemorrhage and hypovolaemic shock, either during delivery or afterwards.
- pituitary failure 1
- may be silent and present with delayed hypopituitarism
- adrenal insufficiency
- hyponatraemia (diabetes insipidus) in the acute setting of extreme hypovolaemia
- growth hormone deficiency
optic chiasm compression
- visual field loss
Hypovolaemia secondary to postpartum haemorrhage leads to pituitary infarction and necrosis.
- enlarged pituitary, with low T1, high T2 homogenous signal
- ring enhancement
- empty sella of normal size 3
- ring enhancement surrounding a low attenuation empty sella 2
History and etymology
It is named after Harold Leeming Sheehan (1900-1988).
- 1. Sert M, Tetiker T, Kirim S et-al. Clinical report of 28 patients with Sheehan's syndrome. Endocr. J. 2004;50 (3): 297-301. Pubmed citation
- 2. Dejager, Gerber, Foubert et-al. Journal of Internal Medicine. 1998;244 (3): . doi:10.1046/j.1365-2796.1998.00370.x
- 3. Fleckman A, Schubart U, Danziger A et-al. The American Journal of Medicine. 1983;75 (4): . doi:10.1016/0002-9343(83)90437-0