Question 1389
{"accessible":false,"alternatives":[{"id":6924,"text":"Alzheimer disease"},{"id":6925,"text":"cerebral amyloid angiopathy"},{"id":6926,"text":"dementia with Lewy bodies"},{"id":6927,"text":"multiple system atrophy (MSA)"},{"id":6928,"text":"Parkinson disease"}],"archived":false,"correctAlternativeId":6927,"explanation":"\u003cp\u003eMultiple system atrophy (MSA) is a sporadic neurodegenerative disease characterized by varying degrees of cerebellar ataxia, autonomic dysfunction, parkinsonism and corticospinal dysfunction. Initially, these various manifestations were described as separate diseases:\u0026nbsp;\u003c/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https://radiopaedia.org/articles/shy-drager-syndrome-2?lang=gb\"\u003eShy-Drager syndrome\u003c/a\u003e: autonomic symptoms predominate\u003c/li\u003e\n\u003cli\u003e\n\u003ca href=\"https://radiopaedia.org/articles/multiple-system-atrophy-parkinsonian-manifestation?lang=gb\"\u003estriatonigral degeneration\u003c/a\u003e:\u0026nbsp;predominant parkinsonian features\u003c/li\u003e\n\u003cli\u003e\n\u003ca href=\"https://radiopaedia.org/articles/olivopontocerebellar-degeneration-msa-c?lang=gb\"\u003eolivopontocerebellar atrophy\u003c/a\u003e:\u0026nbsp;primarily cerebellar dysfunction\u003c/li\u003e\n\u003c/ul\u003e\u003cp\u003eIn a 2007 consensus paper\u0026nbsp;6\u0026nbsp;MSA has been divided clinically into two forms according to the dominant non-autonomic symptoms:\u0026nbsp;\u003c/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eMSA-C:\u003c/strong\u003e\u0026nbsp;predominance of cerebellar symptoms (\u003ca href=\"https://radiopaedia.org/articles/olivopontocerebellar-degeneration-msa-c?lang=gb\"\u003eolivopontocerebellar atrophy\u003c/a\u003e)\u003c/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMSA-P:\u003c/strong\u003e\u0026nbsp;predominance of parkinsonian signs and symptoms (\u003ca href=\"https://radiopaedia.org/articles/multiple-system-atrophy-parkinsonian-manifestation?lang=gb\"\u003estriatonigral degeneration\u003c/a\u003e)\u003c/li\u003e\n\u003c/ol\u003e\u003cp\u003eSome older texts refer to MSA-A to denote Shy-Drager syndrome. In the latest consensus however autonomic symptoms are considered part of both MSA-C and MSA-P and thus the term MSA-A is no longer used.\u003c/p\u003e\u003cp\u003e\u0026nbsp;\u003c/p\u003e","id":1389,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/1389","nextQuestionPath":null,"relatedArticles":[{"id":13001,"title":"Neurodegenerative disease","link":"/articles/neurodegenerative-disease?lang=us"},{"id":7291,"title":"Multiple system atrophy cerebellar type (MSA-C)","link":"/articles/multiple-system-atrophy-cerebellar-type-msa-c?lang=us"},{"id":13006,"title":"Multiple system atrophy parkinsonian type (MSA-P)","link":"/articles/multiple-system-atrophy-parkinsonian-type-msa-p-2?lang=us"}],"alsoUsedIn":[{"id":502,"kind":"Course","title":"Neurodegenerative Learning Pathway - page 502","link":"https://radiopaedia.org/courses/neurodegenerative-learning-pathway/pages/502"},{"id":1065,"kind":"Course","title":"Neurodegenerative Learning Pathway - page 1065","link":"https://radiopaedia.org/courses/neurodegenerative-learning-pathway/pages/1065"}],"stem":"\u003cp\u003eShy-Drager syndrome, striatonigral degeneration and\u0026nbsp;olivopontocerebellar atrophy are now considered manifestations of which of the following diseases?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/1389"}],"attemptsPercentages":[{"alternativeId":"6925","percentage":1},{"alternativeId":"6928","percentage":6},{"alternativeId":"6926","percentage":7},{"alternativeId":"6927","percentage":86},{"alternativeId":"6924","percentage":1}],"promptToLogin":false,"questionManager":false,"articleId":"shy-drager-syndrome"}