Sialosis refers to diffuse, non-inflammatory, non-neoplastic recurrent enlargement of the major salivary glands. It is uncommon and has a variety of systemic causes.
The commonest causes are diabetes mellitus and alcoholism. Other causes include malnutrition, hormonal insufficiency and radiation therapy.
- sparse peripheral ducts
- a normal or enlarged gland
- normal density throughout most of the disease
- end stage glands may be diffusely dense and large