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Sialosis or sialadenosis (plurals: sialoses or sialadenoses) refers to diffuse, non-inflammatory, non-neoplastic recurrent/persistent enlargement of the major salivary glands, caused by hypertrophy of the acinar components. Typically, the parotid gland is most affected, although submandibular gland enlargement is not uncommon.

It is uncommon and has a variety of systemic causes:

The commonest causes are diabetes mellitus (50% of sialosis cases 3) and alcoholism, but some cases have no known underlying systemic disease.

  • sparse peripheral ducts
  • a normal or enlarged gland
  • normal density throughout most of the disease
  • end stage glands may be diffusely dense and large
  • greater fatty infiltration in diabetic sialadenosis
  • reduction of fatty tissue in alcoholic sialadenosis

Article information

rID: 10455
System: Head & Neck
Synonyms or Alternate Spellings:
  • Sialadenoses
  • Sialoses
  • Sialadenosis

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