Sickle cell disease: abdominal manifestations

Abdominal manifestations of sickle cell disease (SCD) are wide and can involve many organs.

For a general discussion, please refer to sickle cell disease.

Splenic
  • splenomegaly
    • splenic enlargement may occur transiently with the sequestration syndrome, where rapid pooling of blood occurs in the spleen, resulting in intravascular volume depletion, with potential for cardiovascular collapse
  • autosplenectomy
    • the slow, tortuous micro-circulation of the spleen renders it susceptible to infarction and subsequent functional asplenia
    • 94% are asplenic by age 51
    • radiological finding is of a small, calcified spleen
  • splenic abscesses
Hepatobiliary
Renal
  • kidneys are often large early in the disease, with variable echogenicity on ultrasound, but shrink with development of renal failure. Bilateral echogenic pyramids are frequently seen in sickle cell disease
  • renal papillary necrosis
  • renal vein thrombosis
Gastrointestinal tract
  • approximately 40% patient may develop peptic ulcers due to reduced mucosal resistance and bowel ischaemia

See also

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Article Information

rID: 12458
Tag: refs
Synonyms or Alternate Spellings:
  • Abdominal manifestations of sickle cell anaemia
  • Abdominal manifestations of sickle cell anemia
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    Sickle Cell Disea...
    Case 1: with autosplenectomy
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    Echogenic Renal P...
    Case 2: with echogenic renal pyramids
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    Sickle cell disea...
    Case 3: with echogenic renal pyramids
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