Sickle cell disease (cerebral manifestations)

Last revised by Ammar Haouimi on 17 May 2022

Cerebral manifestations of sickle cell disease contribute significantly to the overall morbidity of the disease. Sickle cell disease is among the most common causes of stroke in the pediatric population.

For a general discussion of sickle cell disease, please refer to sickle cell disease.

Approximately 25% of patients with sickle cell disease have a neurological event in their lifetime, many of these in childhood 1

Ischemic strokes and cognitive impairment are common, but in many instances, infarcts may be asymptomatic 1-2

Cerebral radiological findings in sickle cell disease include 1-3:

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