Sickle cell disease (skeletal manifestations)

Skeletal manifestations of sickle cell disease result from three interconnected sequelae of sickle cell disease 5

  1. vaso-occlusive crises resulting in bone infarcts and subperiosteal hemorrhages
  2. chronic anemia resulting in expansion of the medullary spaces
  3. infection

These, in turn, can predispose individuals to other complications, such as growth disturbance and pathological fractures.

For a general discussion of sickle cell disease, please refer to sickle cell disease.

Vaso-occlusive crises are common and usually result in skeletal pain. Osteomyelitis will present with localized pain and systemic features of infection. 

The radiographic features will depend on the specific complication and are therefore discussed separately were appropriate. 

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Article information

rID: 12457
Synonyms or Alternate Spellings:
  • Skeletal manifestations of sickle cell anaemia
  • Skeletal manifestations of sickle cell anemia

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Cases and figures

  • Sickle cell disea...
    Case 1: with H-shaped vertebrae
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  • Case 2: with osteosclerosis and H-shaped vertebrae
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  • Case 3: with AVN of the hip
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  • Case 4: with bone infarct
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  • Case 5: with avascular necrosis of the hip
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  • Case 6: with osteomyelitis
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  • Case 7: with H-shaped vertebrae
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