Sinonasal carcinoma

Sinonasal carcinomas are a broad group of sinonasal malignant tumors that are of epithelial cell origin/lineage.

Pathology

Sinonasal carcinomas can be classified into various histological and etiological subgroups:

• sinonasal squamous cell carcinoma: considered the most common histological subtype and accounts for >50% of all sinonasal malignant tumors ¹

• sinonasal adenocarcinoma: considered the second most common and accounts for 20% of all sinonasal malignant tumors; these can be further categorized into ^ref

  • salivary type sinonasal adenocarcinoma

  • non-salivary type sinonasal adenocarcinoma

    • renal cell-like adenocarcinoma of sinonasal cavity​

• sinonasal adenoid cystic carcinoma

• sinonasal undifferentiated carcinoma

• NUT carcinoma / NUT midline carcinoma of sinonasal cavity

Most recently described molecular/etiological subtypes include:

• SMARCB1-deficient sinonasal carcinoma

• HPV-related sinonasal carcinoma

Differential diagnosis

On imaging consider other malignant sino-nasal tumors such as:

• sinonasal melanoma

• sinonasal sarcoma

  • biphenotypic sinonasal sarcoma

• olfactory neuroblastoma

• ​sinonasal lymphoma

• extramedullary plasmacytoma of sinonasal cavity

• rhabdomyosarcoma of sinonasal cavity

See also

• sinonasal disease