Skeletal sarcoidosis is an uncommon manifestation of sarcoidosis.
Skeletal involvement is thought to occur in ~1-13% of patients with sarcoidosis 6,9.
Osseous involvement may be more common in black patients 10.
Patient's with large bone lesions and vertebral lesions may become symptomatic. The exact symptoms may vary depending on site. It may be accompanied by lupus pernio (chronic, predominantly facial skin lesion resembling frostbite 11) or other types of infiltrative skin lesions 10.
Primary skeletal involvement without other organ involvement is extremely rare 3. Approximately 80-90% patients have concurrent pulmonary involvement 6.
The phalanges in the hands and feet are most frequently affected. There is typically multiple joint involvement.
Small bone lesions
Radiographic features may include cyst like radiolucent areas, a lacelike honeycomb appearance (this is typically seen in the hands), or extensive bone erosion with pathologic fractures. The articular spaces are usually intact unless extensive neuropathic lesions develop. A subcutaneous soft-tissue mass or tenosynovitis may also be present.
When there is involvement of other skeletal structures, diagnosis becomes difficult as the condition can mimic various other pathology
Large bone lesions and axial skeletal lesions
Large bone lesions may manifest radiographically as either focal lytic or sclerotic areas. They may even be occult.
In the vertebrae, sarcoidosis can cause osteolytic lesions and disc spaces are usually preserved. Widespread vertebral sclerosis can also occur.
They have been secondary alignment abnormalities deformities due to pathologic fractures with bone collapse.
MRI may demonstrate fine perpendicular lines extending from the ghost of the cortex and resembling periostitis 5.
Intermediate-density–weighted MR imaging sarcoidal nodules are typically hyperintense 5.
MR imaging of large bony lesions usually reveals indistinct or well-marginated lesions of varying sizes.
Reported signal characteristics include:
- T1: large bone lesions are typical low signal
- inversion recovery: can have high signal
- T2 / PD FS: most cases are high signal
- C+ (Gd): lesions may enhance
Scintigraphic findings become usually positive even before the lesions become manifest at radiography. Both Tc99m methylene diphosphonate and Ga67 citrate imaging may show uptake.
FDG-PET/CT has shown promising results in the detection of extra-thoracic involvement including skeletal lesions 12-14.
While classical hand lesions have characteristic features, there is a wide differential for skeletal involvement in other sites
For vertebral lesions, consider
For calvarial lesions also additionally consider
- 1. Ludwig V, Fordice S, Lamar R et-al. Unsuspected skeletal sarcoidosis mimicking metastatic disease on FDG positron emission tomography and bone scintigraphy. Clin Nucl Med. 2003;28 (3): 176-9. doi:10.1097/01.RLU.0000053528.35645.70 - Pubmed citation
- 2. Nijjar SS, Leslie WD. A case of skeletal sarcoidosis imitating skeletal metastases on bone scintigraphy. CMAJ. 2008;178 (2): 153-4. CMAJ (full text) - doi:10.1503/cmaj.070419 - Free text at pubmed - Pubmed citation
- 3. Talmi D, Smith S, Mulligan ME. Central skeletal sarcoidosis mimicking metastatic disease. Skeletal Radiol. 2008;37 (8): 757-61. Skeletal Radiol. (full text) - doi:10.1007/s00256-008-0479-7 - Pubmed citation
- 4. Koyama T, Ueda H, Togashi K et-al. Radiologic manifestations of sarcoidosis in various organs. Radiographics. 2004;24 (1): 87-104. Radiographics (full text) - doi:10.1148/rg.241035076 - Pubmed citation
- 5. Moore SL, Teirstein AE. Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging. Radiographics. 2003;23 (6): 1389-99. Radiographics (full text) - doi:10.1148/rg.236025172 - Pubmed citation
- 6. Fisher AJ, Gilula LA, Kyriakos M et-al. MR imaging changes of lumbar vertebral sarcoidosis. AJR Am J Roentgenol. 1999;173 (2): 354-6. AJR Am J Roentgenol (citation) - Pubmed citation
- 7. Ginsberg LE, Williams DW, Stanton C. MRI of vertebral sarcoidosis. J Comput Assist Tomogr. 17 (1): 158-9. - Pubmed citation
- 8. Lisle D, Mitchell K, Crouch M et-al. Sarcoidosis of the thoracic and lumbar spine: imaging findings with an emphasis on magnetic resonance imaging. Australas Radiol. 2004;48 (3): 404-7. Australas Radiol (full text) - doi:10.1111/j.0004-8461.2004.01328.x - Pubmed citation
- 9. Poyanli A, Poyanli O, Sencer S et-al. Vertebral sarcoidosis: imaging findings. Eur Radiol. 2000;10 (1): 92-4. Eur Radiol (link) - Pubmed citation
- 10. Nessrine A, Zahra AF, Taoufik H. Musculoskeletal involvement in sarcoidosis. J Bras Pneumol. 2014;40 (2): 175-82. Free text at pubmed - Pubmed citation
- 11. Anjaneyan G, Vora R. Lupus pernio without systemic involvement. Indian Dermatol Online J. 2013;4 (4): 314-7. doi:10.4103/2229-5178.120656 - Free text at pubmed - Pubmed citation
- 12. Soussan M, Augier A, Brillet PY et-al. Functional imaging in extrapulmonary sarcoidosis: FDG-PET/CT and MR features. Clin Nucl Med. 2014;39 (2): e146-59. doi:10.1097/RLU.0b013e318279f264 - Pubmed citation
- 13. Promteangtrong C, Salavati A, Cheng G et-al. The role of positron emission tomography-computed tomography/magnetic resonance imaging in the management of sarcoidosis patients. Hell J Nucl Med. 2014;17 (2): 123-35. Pubmed citation
- 14. Caobelli F, Gabanelli SV, Brucato A et-al. Unsuspected Active Sarcoidosis Diagnosed by 18F-FDG PET/CT During the Search for a Primary Tumour in a Patient with Bone Lesions. Nucl Med Mol Imaging. 2013;47 (3): 205-7. doi:10.1007/s13139-013-0203-y - Free text at pubmed - Pubmed citation