Sneddon syndrome is a type of systemic non-inflammatory vasculopathy characterised by livedo reticularis and progressive and occlusive cerebrovascular thrombosis involving the medium size arteries.
It is characterized by intimal hyperplasia of medium sized arteries with unknown aetiology. Half of the patients also have antiphospholipid antibody syndrome. Skin biopsy is diagnostic.
- livedo reticularis as a skin manifestation
- progressive cerebral strokes and haemorrhage
- cerebral dysfunction
CT and MRI show non specific infarcts, cortical atrophy, lacunar infarcts. Angiogram shows medium size artery stenosis or occlusion and large networks of collateral small vessel formation.
There is no effective treatment to control the disease progression but long-term antiplatelet therapy and anticoagulation are commonly used in cases with cerebral manifestation.
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