Solitary bone plasmacytoma

Dr Rohit Sharma and Dr Bruno Di Muzio et al.

Solitary bone plasmacytomas is an uncommon plasma cell tumor which is localized to bone. They may involve any bone, but they have a predisposition for the red marrow-containing axial skeleton:

  • spinal disease is observed in ~50% (range 34-72%) of cases
  • the thoracic vertebrae are most commonly involved, followed by lumbar, sacral, and cervical vertebrae
  • the rib, sternum, clavicle, or scapula is involved in 20% of cases

Solitary bone plasmacytoma is one of the two subgroups of plasmacytoma, the other being the extramedullary plasmacytoma.

  • peak incidence is in 4th to 6th decades
  • more common in males ~2:1

Physical findings are related to the site of involvement, presenting as a painful mass, pathologic fracture, or root or spinal cord compression syndrome.

The most common symptom of solitary bone plasmacytoma is a pain at the site of the skeletal lesion due to bone destruction by the infiltrating plasma cell tumor.

Patients with long bone involvement may present with pathologic fracture.

Diagnostic criteria for solitary bone plasmacytoma has been considered as follows 1:

  • single area of destruction due to clonal plasma cells
  • bone marrow plasma cell infiltration <5% of all nucleated cells
  • absence of osteolytic bone lesions or other tissue involvement (i.e. no evidence of myeloma)
  • absence of anemia, hypercalcemia or renal impairment (usually attributable to myeloma)
  • low or absent serum/urine monoclonal protein
  • preserved levels of uninvolved immunoglobulins

Solitary expansile lytic lesion with thinning and destruction of the cortex, and bubbly/trabeculated appearance. Characteristically, the absence of sclerotic reaction is seen.

Expansile lytic lesion with thinned out cortex and characteristic 'mini-brain' appearance has been described in solitary vertebral lesions.

A mini-brain appearance has also been described on MRI 3. It is seen as curvilinear low signal intensity areas within the lesion, giving an appearance of sulci in the brain. In fact, this appearance is so characteristic that it may obviate the need for a diagnostic biopsy.

Signal characteristics include:

  • T1: hypo- to isointense
  • T2: iso- to hyperintense to muscle
  • T1 C+ (Gd): variable enhancement

Excision of the tumor and its extent is done, with chemo-radiotherapy as an adjuvant. Local recurrence is less than 5% and dissemination is seen in 35-70% of patients. The disease may progress to multiple myeloma, with a bad prognosis.

General imaging differential considerations include:

Bone tumours

The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.

Article information

rID: 12539
Synonyms or Alternate Spellings:
  • Solitary bone plasmacytoma (SBP)
  • Solitary myeloma
  • Pseudoplasma cell granuloma
  • Benign myeloma
  • Solitary bone plasmacytomas
  • Solitary myelomas
  • Mini-brain appearance
  • Mini brain sign

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Cases and figures

  • Case 1
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  • Case 1
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  • Case 2
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  • Case 3: vertebral "mini-brain" appearance
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  • Case 4
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