Solitary pulmonary nodule (an approach)
A solitary pulmonary nodule, according to the Nomenclature Committee of the Fleischner Society, defined as a rounded opacity, well or poorly defined on a conventional radiograph, measuring up to 3 cm in diameter and is not associated with lymphadenopathy, atelectasis, or pneumonia.
Several radiographic parameters have been described for the risk assessment of a lung nodule to include or exclude possible chances of malignancy. These radiographic features must be kept in the mind while evaluating a solitary pulmonary nodule:
Generally, a nodule greater than 7 mm in a patient above 40 years of age is considered to be associated with increased risk of malignancy. Nodule size and risk of malignancy observed:
- <5 mm: <1%
- 5-10 mm: 6-28%
- >20 mm: 64-82%
Nodule growth rate
If previous radiographs are available, the growth rate of a nodule can be calculated in terms of doubling time. Cancerous lesions have a doubling time of 1-18 months.
Benign lesions like granulomas and intrapulmonary lymph nodes generally occur more peripherally, particularly in subpleural regions. Most of the primary lung cancer affect upper lobe (right>left) and majority of metastatic lesions show lower lobe predominance.
Well defined and smooth margins are features of benign lesions while in malignant lesions, margins are more ill-defined/spiculated/undulated due to desmoplastic reaction or infiltration of interstitium by the tumour cells.
Calcification within nodule
Various types of calcifications within the nodule have been described. Dense, solid and laminated calcifications are most commonly seen in old granulomas. Popcorn calcification is a feature of hamartoma. Calcifications in malignant nodules are fine, dendriform and punctate.
Fat within nodule
Cavitation within nodule
Cavitation within nodule increases the risk of possible malignancy especially if the cavity is thick walled and irregular in shape. Although benign lesions may also cavitate but these cavities are generally thin walled and round.
Partly solid nodules are more likely to be malignant than pure solid or fluid containing nodules.
High-density lesions on CT are more likely to be benign.
Enhancement is related to vascularity and more enhancement is associated with increased risk. Malignant lesions show average enhancement of 40 HU (20-108 HU) which is significantly higher than that of benign granulomas of average 12 HU (-4-58 HU). An enhancement less than 15 HU is highly suggestive of benignity.
Dynamic contrast-enhanced MRI has shown that malignant nodules show early peak enhancement and faster washout.
Feeding vessel sign
- 1. Khan AN, Al-Jahdali HH, Irion KL et-al. Solitary pulmonary nodule: A diagnostic algorithm in the light of current imaging technique. Avicenna J Med. 2011;1 (2): 39-51. doi:10.4103/2231-0770.90915 - Free text at pubmed - Pubmed citation
- 2. Wahidi MM, Govert JA, Goudar RK et-al. Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132 (3_suppl): 94S-107S. doi:10.1378/chest.07-1352 - Pubmed citation
- 3. Grgic A, Yüksel Y, Gröschel A et-al. Risk stratification of solitary pulmonary nodules by means of PET using (18)F-fluorodeoxyglucose and SUV quantification. Eur. J. Nucl. Med. Mol. Imaging. 2010;37 (6): 1087-94. doi:10.1007/s00259-010-1387-3 - Pubmed citation