Sonographic Murphy sign (SMS) is defined as maximal abdominal tenderness from pressure of the ultrasound probe over the visualised gallbladder 1,2.
SMS is a sign of local inflammation around the gallbladder along with right upper quadrant pain, tenderness or mass 2.
It is one of the most important sonographic signs of cholecystitis and when combined with the presence or absence of cholelithiasis it has a high positive and negative predictive value respectively 3.
- 1. Bree RL. Further observations on the usefulness of the sonographic Murphy sign in the evaluation of suspected acute cholecystitis. J Clin Ultrasound. 1995;23 (3): 169-72. Pubmed citation
- 2. Kiewiet JJ, Leeuwenburgh MM, Bipat S et-al. A systematic review and meta-analysis of diagnostic performance of imaging in acute cholecystitis. Radiology. 2012;264 (3): 708-20. Radiology (full text) - doi:10.1148/radiol.12111561 - Pubmed citation
- 3. Noble VE, Liteplo AS, Nelson BP et-al. The impact of analgesia on the diagnostic accuracy of the sonographic Murphy's sign. Eur J Emerg Med. 2010;17 (2): 80-3. doi:10.1097/MEJ.0b013e32832e9627 - Pubmed citation