Splenic amyloidosis

Splenic amyloidosis is rare as an isolated entity. Most often it is associated with either systemic amyloidosis or hepatic amyloidosis.

In general splenic involvement in amyloidosis is rather frequent (5-10% of cases 6).

Symptoms include abdominal mass and abdominal (left upper quadrant) pain.

Complications
Plain radiograph

Not sensitive of specific but may show splenomegaly.

CT 
  • splenomegaly
  • non-contrast CT shows ill-defined heterogeneous lesions 
  • post contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis
MRI
  • splenomegaly
  • T2: affected regions may show decreased signal intensity 1

Imaging differential considerations include splenic involvement with:

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Article information

rID: 25650
Section: Gamuts
Tag: cases
Synonyms or Alternate Spellings:
  • Amyloidosis of spleen
  • Amyloidosis involving the spleen

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