Splenic amyloidosis

Last revised by Daniel J Bell on 21 Jun 2021

Splenic amyloidosis is rare as an isolated entity. Most often it is associated with either systemic amyloidosis or hepatic amyloidosis.

In general, splenic involvement in amyloidosis is rather frequent (5-10% of cases 6,7).

Symptoms include abdominal mass and left upper quadrant pain.

Plain radiography is neither sensitive nor specific but may show splenomegaly.

  • splenomegaly
  • calcification is rarely seen 7
  • non-contrast CT shows ill-defined heterogeneous lesions
  • post-contrast CT shows heterogeneous enhancement and hypoperfusion of spleen, which is one of the important indicators of systemic amyloidosis
  • splenomegaly
  • T2: affected regions may show decreased signal intensity 1,7

Imaging differential considerations include splenic involvement with:

ADVERTISEMENT: Supporters see fewer/no ads