Citation, DOI and article data
Splenic epithelial cysts, also known as splenic epidermoid cysts or primary splenic cysts, are unilocular fluid lesions with thin and smooth walls and no enhancement. They represent ~20% of cysts found in the spleen, and are usually an innocuous incidental imaging finding.
Note that most (~80%) simple-appearing cystic splenic lesions represent secondary cysts or pseudocysts (see Differential diagnosis section below).
In practice, both primary and secondary cysts are often described simply as "splenic cyst" for the sake of simplicity, as often the specific etiology is not evident.
They are thought to account for 20% of benign non-parasitic cysts of the spleen 5,8. There may be an increased female predilection.
The clinical presentation can vary ranging from being incidentally discovered on routine imaging to having nausea, vomiting, vague abdominal pain or rarely painful splenomegaly, particularly when the cysts are large.
They are congenital in origin. As “true” cysts, they have an epithelial lining formed secondary to the unfolding of peritoneal mesothelium or collections of peritoneal mesothelial cells trapped within the splenic sulci. A genetic defect of mesothelial migration is considered the cause. While most are sporadic, rarely there is a familial occurrence. They typically grow slowly and are usually large (around 10 cm) at the time of discovery. They are solitary in 80%. Peripheral calcifications are uncommon (10-15%).
Usually shows an anechoic to hypoechoic well defined intrasplenic lesion. Internal echoes may be present due to debris. Their margin may be echogenic with distal shadowing due to calcifications 8.
Typically shows a hypoattenuating relatively well-defined intrasplenic lesion. The wall is thin and has a sharp demarcation to the splenic parenchyma. There is no rim or internal enhancement. Wall calcification may be present.
Well-defined cystic lesions with internal homogeneous fluid signal intensity:
- T1: low signal intensity
- T2: very high signal intensity
Treatment and prognosis
Small and asymptomatic cysts do not require treatment or followup. Symptomatic cysts are managed surgically.
Complications are rare and include hemorrhage, rupture and infection 6,7.
A number of splenic lesions may appear cystic, depending on the modality:
- secondary cysts (~80% of all splenic cysts)
- other congenital cystic lesions (tend to be unilocular in a majority of cases)
- splenic bacterial abscess
- cystic splenic metastases
- splenic lymphoma: although may appear nearly anechoic, hypoechoic lymphoma tends to have less distinct margins than a cyst 10
- splenic peliosis 11,12
- 1. Dachman AH, Ros PR, Murari PJ et-al. Nonparasitic splenic cysts: a report of 52 cases with radiologic-pathologic correlation. AJR Am J Roentgenol. 1986;147 (3): 537-42. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Brant WE, Helms CA. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2006) ISBN:0781765188. Read it at Google Books - Find it at Amazon
- 3. McGahan JP, Goldberg BB. Diagnostic Ultrasound. Informa Health Care. (2008) ISBN:1420069780. Read it at Google Books - Find it at Amazon
- 4. Macheras A, Misiakos EP, Liakakos T et-al. Non-parasitic splenic cysts: a report of three cases. World J. Gastroenterol. 2006;11 (43): 6884-7. Pubmed citation
- 5. Shirkhoda A, Freeman J, Armin AR et-al. Imaging features of splenic epidermoid cyst with pathologic correlation. Abdom Imaging. 1995;20 (5): 449-51. Pubmed citation
- 6. Spencer NJ, Arthur RJ, Stringer MD. Ruptured splenic epidermoid cyst: case report and imaging appearances. Pediatr Radiol. 1997;26 (12): 871-3. Pubmed citation
- 7. Matsubayashi H, Kuraoka K, Kobayashi Y et-al. Ruptured epidermoid cyst and haematoma of spleen: a diagnostic clue of high levels of serum carcinoembryonic antigen, carbohydrate antigen 19-9 and Sialyl Lewis x. Dig Liver Dis. 2002;33 (7): 595-9. Pubmed citation
- 8. Lee HJ, Kim JW, Hong JH, Kim GS, Shin SS, Heo SH, Lim HS, Hur YH, Seon HJ, Jeong YY. Cross-sectional Imaging of Splenic Lesions: RadioGraphics Fundamentals | Online Presentation. (2018) Radiographics : a review publication of the Radiological Society of North America, Inc. 38 (2): 435-436. doi:10.1148/rg.2018170119 - Pubmed
- 9. Elsayes KM, Narra VR, Mukundan G, Lewis JS, Menias CO, Heiken JP. MR imaging of the spleen: spectrum of abnormalities. (2005) Radiographics : a review publication of the Radiological Society of North America, Inc. 25 (4): 967-82. doi:10.1148/rg.254045154 - Pubmed
- 10. Ishida H, Konno K, Ishida J, Naganuma H, Komatsuda T, Sato M, Watanabe S. Splenic lymphoma: differentiation from splenic cyst with ultrasonography. (2001) Abdominal imaging. 26 (5): 529-32. Pubmed
- 11. Urrutia M, Mergo PJ, Ros LH, Torres GM, Ros PR. Cystic masses of the spleen: radiologic-pathologic correlation. (1996) Radiographics : a review publication of the Radiological Society of North America, Inc. 16 (1): 107-29. doi:10.1148/radiographics.16.1.107 - Pubmed
- 12. Davidson J, Tung K. Splenic peliosis: an unusual entity. (2010) The British journal of radiology. 83 (990): e126-8. doi:10.1259/bjr/71300465 - Pubmed