Splenic infarction is a result of ischaemia to the spleen, and in many cases requires no treatment. However, identification of the cause of infarction is essential.
Splenic infarcts can occur due to a number of processes, involving either arterial supply, the spleen itself or the venous drainage. As such there is no one affected demographic; rather the demographics will vary with the underlying cause.
Patients with a splenic infarction may present with left upper quadrant pain. Some may have constitutional symptoms such as fevers and chills while others may even have diffuse abdominal pain 5,9. Due to the location of the spleen, tucked under the left hemidiaphragm, referred pain to the left shoulder is also a feature 9.
It should be noted that ~40% (range 30-50%) of patients with splenic infarction are asymptomatic 9.
The majority of patients with splenic infarcts have one of the following two aetiologies:
- haematologic disorders
- more common in younger patients
- e.g. sickle cell disease
- hypercoagulable states
- embolic events
Other aetiological factors include 1,2:
- splenic vascular disease
- splenic arterial aneurysms 7
- variant anatomy, e.g. wandering spleen, which may undergo splenic torsion
- collagen vascular disease
- pancreatitis 8
- non-haematologic malignancies
- blunt trauma: a segmental splenic infarct can occur as a rare complication 4
- splenic artery compression, e.g. by pancreatic tumour
- splenic embolisation
- leukaemia (CML most common) 16
The appearance of splenic infarction depends on the timing of imaging and the size of the infarct. Although once the infarct has become established, both ultrasound and CT are sensitive to the diagnosis, in the hyperacute setting CT with contrast is the modality of choice if the diagnosis is suspected 9.
Morphologically the typical infarct is of a pyramidal wedge of affected splenic tissue with the apex pointing towards the hilum, and the base on the splenic capsule.
As the infarct matures, the wedge of infarcted tissue can undergo one of three processes which will dictate imaging features:
- resolution: no imaging findings
Typically infarcts are hypoechoic compared to the rest of the spleen, although acutely they can be isoechoic and hard to identify. Sonographic features of acute splenic infarcts regarding shape can vary and include 5,9:
- wedge-shaped (classic)
- smooth (uncommon)
During contrast-enhanced ultrasound, the infarcted area remains hypointense throughout all phases of the study 10.
As the infarct matures, if it undergoes contraction and scarring it will appear as a hyperechoic region with retraction of the capsule 9. If liquefaction occurs, the area may be rounded and anechoic (splenic pseudocyst).
CT is often considered the imaging investigation of choice, ideally performed during the portal venous phase, to avoid confusing heterogeneous enhancement normally seen during arterial phase 2,7,9. Imaging features may vary with the stage of the infarct.
In the hyperacute phase, CT may show areas of mottled increased attenuation, representing areas of a haemorrhagic infarction.
There are various classical and non-classical patterns of established splenic infarcts on CT, which include 3,9:
- peripheral, wedge-shaped hypoenhancing region: typical
- multiple, heterogeneous areas of patchy enhancement
- global splenic infarction, entire spleen is hypoenhancing, e.g. in splenic torsion
- infarction of a splenunculus 9
In the chronic phase, infarcts may disappear completely, but more commonly, they may reveal progressive volume loss caused by fibrotic contraction of the infarct, with hypertrophy of the surrounding normal spleen 7,9. Alternatively, if the infarct liquefies, a cystic lesion may be left with fluid density centrally 9.
Treatment and prognosis
Initial management usually consists of hydration, analgesics, and frequent monitoring, with the resolution of symptoms in 7-14 days. Splenectomy was performed for persistent symptoms or complications.
Some complications are encountered, more frequently in patients with an embolic aetiology. These include:
- formation of a splenic pseudocyst(s)
- infected splenic infarction leading to the formation of a splenic abscess
- splenic haemorrhage
- splenic rupture
Often, when imaging appearances are typical, there is little differential diagnosis. When less typical, or when imaging is suboptimal, alternative diagnoses should be entertained, including 9:
- normal inhomogeneous splenic enhancement (zebra or psychedelic spleen): seen during arterial phase CT
- either primary or superimposed infection on a liquefied infarct
- history of trauma
- surrounding haematoma
- note: splenic rupture can complicate infarction
- 1. Jaroch MT, Broughan TA, Hermann RE. The natural history of splenic infarction. Surgery. 1986;100 (4): 743-50. - Pubmed citation
- 2. Nores M, Phillips EH, Morgenstern L et-al. The clinical spectrum of splenic infarction. Am Surg. 1998;64 (2): 182-8. - Pubmed citation
- 3. Balcar I, Seltzer SE, Davis S et-al. CT patterns of splenic infarction: a clinical and experimental study. Radiology. 1984;151 (3): 723-9. Radiology (abstract) - Pubmed citation
- 4. Miller LA, Mirvis SE, Shanmuganathan K et-al. CT diagnosis of splenic infarction in blunt trauma: imaging features, clinical significance and complications. Clin Radiol. 2004;59 (4): 342-8. doi:10.1016/j.crad.2003.09.005 - Pubmed citation
- 5. Goerg C, Schwerk WB. Splenic infarction: sonographic patterns, diagnosis, follow-up, and complications. Radiology. 1990;174 (3): 803-7. Radiology (abstract) - Pubmed citation
- 6. Balthazar EJ, Hilton S, Naidich D et-al. CT of splenic and perisplenic abnormalities in septic patients. AJR Am J Roentgenol. 1985;144 (1): 53-6. AJR Am J Roentgenol (abstract) - Pubmed citation
- 7. Rabushka LS, Kawashima A, Fishman EK. Imaging of the spleen: CT with supplemental MR examination. Radiographics. 1994;14 (2): 307-32. Radiographics (abstract) - Pubmed citation
- 8. Collie DA, Ferguson JM, Allan PL et-al. Case report: computed tomography features of complete splenic infarction, cavitation and spontaneous decompression complicating pancreatitis. Br J Radiol. 1995;68 (810): 662-4. doi:10.1259/0007-1285-68-810-662 - Pubmed citation
- 9. Scaglione M, Schueller MS. Emergency Radiology of the Abdomen. (2012) ISBN:8847025133. Read it at Google Books - Find it at Amazon
- 10. Popescu A, Sporea I, Sirli R, Danila M, Nicolita D, Martie A: The role of contrast-enhanced ultrasonography with second generation contrast agents in the evaluation of focal splenic lesions. Med Ultrason 2009;11: 61-65. - accessible on - http://www.medultrason.ro/assets/Magazines/Medultrason-2009-vol11-no3/09Popescu-61-65.pdf
- 11. Jasarevic M, Laird C, Widlus DM. Splenic infarction associated with bacterial endocarditis and aortic valve vegetations. J Community Hosp Intern Med Perspect. 2012;2 (3): . doi:10.3402/jchimp.v2i3.19299 - Free text at pubmed - Pubmed citation
- 12. Thabah MM, Kumar M, Ramesh A et-al. A case of vivax malaria with splenic infarction. J Vector Borne Dis. 2013;50 (1): 74-6. Pubmed citation
- 13. Donnelly LF, Foss JN, Frush DP, Bisset GS. Heterogeneous splenic enhancement patterns on spiral CT images in children: minimizing misinterpretation. Radiology. 210 (2): 493-7. doi:10.1148/radiology.210.2.r99fe16493 - Pubmed
- 14. Fonner BT, Nemcek AA, Boschman C. CT appearance of splenic infarction in Wegener's granulomatosis. AJR. American journal of roentgenology. 164 (2): 353-4. doi:10.2214/ajr.164.2.7839968 - Pubmed
- 15. Lopez F, Mega A, Schiffman F, Sweeney J. Splenic infarction from factor V Leiden mutation. (1999) American journal of hematology. 62 (1): 62-3. Pubmed
- 16. Green T, Rabinovitz A, Sinelnikov I, et al. Acute myelogenous leukemia with splenic infarcts presenting as fulminant multi-organ failure. (2003) Leukemia & lymphoma. 44 (12): 2143-5. Pubmed
- normal appearance of the spleen
- pseudolesion of the spleen: inhomogeneous splenic enhancement
splenic lesions and anomalies
- congenital anomalies
- mass lesions
- infiltrative processes
- incidental splenic lesion (approach)