Citation, DOI, disclosures and article data
Citation:
Knipe H, Kogan J, Sheikh Y, et al. Splenic metastases. Reference article, Radiopaedia.org (Accessed on 28 Mar 2025) https://doi.org/10.53347/rID-35112
Splenic metastases are relatively rare on imaging and are more commonly encountered at autopsy. Typically they are part of a widespread metastatic disease.
The rate of splenic metastases varies between 1-10% of autopsy studies, depending on whether microscopic or macroscopic metastases were included 1.
Most commonly metastases are a solitary splenic (solid or cystic) mass, may rarely be infiltrative 1,4. Primary sources include 1,2,5:
Ultrasound
solitary or multiple well-defined masses
most commonly appear as a hypoechoic lesion (target appearance), although can be iso- or hyperechoic 3,5
contrast-enhanced US (CEUS): rapid wash-in and wash-out 5
CT
MRI
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1. Compérat E, Bardier-Dupas A, Camparo P et-al. Splenic metastases: clinicopathologic presentation, differential diagnosis, and pathogenesis. Arch. Pathol. Lab. Med. 2007;131 (6): 965-9. Pubmed citation
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2. Iype S. Postgraduate Medical Journal.78 (917): . doi:10.1136/pmj.78.917.173
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3. Schmidt G. Differential diagnosis in ultrasound. Thieme. ISBN:1588901793. Read it at Google Books - Find it at Amazon
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4. Osborn A, Blaser S, Salzman K. Encyclopedia of Diagnostic Imaging. AMIRSYS. (2008) ISBN:0721629059. Read it at Google Books - Find it at Amazon
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5. Lee HJ, Kim JW, Hong JH, Kim GS, Shin SS, Heo SH, Lim HS, Hur YH, Seon HJ, Jeong YY. Cross-sectional Imaging of Splenic Lesions: RadioGraphics Fundamentals | Online Presentation. (2018) Radiographics : a review publication of the Radiological Society of North America, Inc. 38 (2): 435-436. doi:10.1148/rg.2018170119 - Pubmed
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6. Kaur Grewal S, Doley RP, Roy K, Singla M, Malhotra M, Bawa AS, Kapoor R, Wig JD. Isolated splenic metastasis from clear cell renal carcinoma - A case report. (2016) International journal of surgery case reports. 29: 44-46. doi:10.1016/j.ijscr.2016.10.045 - Pubmed
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7.Y Sakuma, Y Yasuda, N Sata, et al. Pancreatic neuroendocrine tumor with metastasis to the spleen: a case report. (2017) BMC Cancer. 17 (1): 37. doi:10.1186/s12885-016-3020-8 - Pubmed
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8. Chen D, Meng X, Zhao Y, Wu S. Isolated splenic metastasis from a thymic carcinoma: A case report. (2016) Cancer biology & therapy. 17 (9): 911-4. doi:10.1080/15384047.2016.1210738 - Pubmed
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9. Naseem, Jan, Britton, Nargund. Splenic metastasis from adenocarcinoma of the prostate. (1998) British Journal of Urology. 82 (4): 597. doi:10.1046/j.1464-410X.1998.00786.x
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10. Sanyal S, Kaman L, Sinha SK. Splenic metastasis from esophageal cancer: report of a case. (2005) Surgery today. 35 (11): 988-90. doi:10.1007/s00595-005-3029-0 - Pubmed
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