Splenic peliosis

Last revised by Liz Silverstone on 23 Jul 2021

Splenic peliosis is an unusual benign disorder characterized by the presence of irregular cystic blood-filled cavities.

Most patients are asymptomatic although very rarely, a patient can present with spontaneous rupture of the spleen.

Recognized associations include

May be seen as an echogenic mass lesion with numerous poorly defined foci of varying hypoechogenicity 5

On non-contrast-enhanced CT images, typically seen as a hypo-attenuating, multi-loculated lesion with well-defined septa within.

On contrast-enhanced CT images, the lesion may show significant enhancement with loss of definition of the lobules and septa. Fluid–fluid levels may also be present.

The term originates from the Greek pelios (Πήλιος), meaning dusky or purple, which arose from the macroscopic appearance of the lesion.

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