Splenic siderotic nodules

Splenic siderotic nodules, also known as Gamna-Gandy bodies, of the spleen, are most commonly encountered in portal hypertension. The pathophysiological process is the result of microhaemorrhage resulting in haemosiderin and calcium deposition followed by fibroblastic reaction.

Grossly, Gamna-Gandy bodies are characterised by many well-circumscribed nodules measuring several millimetres, with a dark haemorrhagic centre surrounded by a pale inner hyperemic rim and a dark outer rim. This gives an appearance resembling "tobacco flecks". Histologically, there is deposition of hemosiderin and calcium within the connective tissue stroma and vessels with a fibroblastic reaction, leading to microarchitectural distortion.

Associations

Recognised associations include 4

Ultrasound

Multiple tiny echogenic foci without acoustic shadowing.

MRI

Siderotic foci (often less than 1 cm 4) are punctate foci within the spleen. The high magnetic susceptibility effect of haemosiderin typically renders the siderotic foci markedly hypointense on certain sequences. Hence, signal characteristics of the nodules include:

  • T2: very low-signal
  • gradient echo (GE) / SWI: low-signal (considered the most sensitive sequence for detection of siderotic nodules 1)
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Article information

rID: 16487
Tag: cases
Synonyms or Alternate Spellings:
  • Siderotic nodules in spleen
  • Siderotic nodules in the spleen
  • Gamna-Gandy bodies
  • Splenic siderotic nodule
  • Gamna-Gandy body

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