Splenic siderotic nodules

Splenic siderotic nodules, also known as Gamna-Gandy bodies, of the spleen, are most commonly encountered in portal hypertension. The pathophysiological process is the result of microhemorrhage resulting in hemosiderin and calcium deposition followed by fibroblastic reaction.

Grossly, Gamna-Gandy bodies are characterized by many well-circumscribed nodules measuring several millimeters, with a dark hemorrhagic center surrounded by a pale inner hyperemic rim and a dark outer rim. This gives an appearance resembling "tobacco flecks". Histologically, there is deposition of hemosiderin and calcium within the connective tissue stroma and vessels with a fibroblastic reaction, leading to microarchitectural distortion.

Recognized associations include 4

Multiple tiny echogenic foci without acoustic shadowing.

Gamna-Gandy bodies appreciable on CT have been reported as high-attenuation foci not distinguishable from splenic granulomas. They are rarely well demonstrated by CT. 2

Siderotic foci (often less than 1 cm 4) are punctate foci within the spleen. The high magnetic susceptibility effect of hemosiderin typically renders the siderotic foci markedly hypointense on certain sequences. Hence, signal characteristics of the nodules include:

  • T2: very low-signal
  • gradient echo (GE) / SWI: low-signal (considered the most sensitive sequence for detection of siderotic nodules 1)

Article information

rID: 16487
Synonyms or Alternate Spellings:
  • Splenic siderosis
  • Siderotic nodules in spleen
  • Siderotic nodules in the spleen
  • Gamna-Gandy bodies
  • Splenic siderotic nodule
  • Gamna-Gandy body

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Cases and figures

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