Squamous cell carcinoma (urinary bladder)

Last revised by Daniel J Bell on 13 Dec 2022

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Bell D, Elfeky M, et al. Squamous cell carcinoma (urinary bladder). Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-9845

DOI:

https://doi.org/10.53347/rID-9845

Permalink:

https://radiopaedia.org/articles/9845

rID:

9845

Article created:

27 May 2010, Frank Gaillard ◉ ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

13 Dec 2022, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no financial relationships to ineligible companies to disclose.

View Daniel J Bell's current disclosures

Revisions:

15 times, by 11 contributors - see full revision history and disclosures

Systems:

Urogenital, Oncology

Tags:

bladder

Synonyms:

SCC of the bladder
Bladder SCC
Bladder squamous cell carcinoma
Squamous cell carcinoma of the bladder
Squamous cell carcinoma of the urinary bladder
SCC of the urinary bladder

Squamous cell carcinoma (SCC) of the urinary bladder is rare, nevertheless SCC is the most common type of non-transitional cell carcinoma involving the bladder ². Most bladder cancers are transitional/urothelial cell carcinomas. SCC is much more common where Schistosomiasis infections are more prevalent.

Squamous cell carcinoma tumours tend to be solitary and large at the time of detection, with muscular wall invasion reported in a high proportion of patients.

Epidemiology

Squamous cell carcinoma of the bladder represents only ~3-8% ^1,2of all bladder cancers (90% are transitional/urothelial cell carcinomas) but nevertheless, SCC is the most common type of non-transitional cell carcinoma involving the bladder ². SCC of the bladder is observed more frequently in Egypt, where Schistosomiasis infections are more frequent than, for example, the UK and US.

Squamous cell carcinoma of the bladder is most commonly seen in the setting of chronic irritation, such as that seen from bladder stones.

Risk factors

antecedent infection with Schistosomiasis
chronic irritation, e.g. indwelling catheter, bladder calculi
chronic infection
intravesical BCG (Bacillus Calmette-Guerin)

Treatment and prognosis

Memorial Sloan-Kettering Cancer Centre has published online a nomogram for estimating the risk of bladder recurrence 5 years post-surgery (concordance index 0.75)⁴.