Squamous cell carcinoma (urinary bladder)

Last revised by Dr Matt A. Morgan on 24 May 2021

Squamous cell carcinoma of the urinary bladder is rare and accounts for only ~3-8% 1,2 of all bladder cancers (90% are transitional/urothelial cell carcinomas) but nevertheless, SCC is the most common type of non-transitional cell carcinoma involving the bladder 2. SCC of the bladder is observed more frequently in Egypt, where Schistosomiasis infections are more frequent than, for example, the UK and US.

Squamous cell carcinoma of the bladder is most commonly seen in the setting of chronic irritation, such as that seen from bladder stones

These tumors tend to be solitary and large at the time of detection, with muscular wall invasion reported in a high proportion of patients.

Risk factors
Recurrence Nomogram

Memorial Sloan-Kettering Cancer Center has published online a nomogram for estimating the risk of bladder recurrence 5 years post-surgery (concordance index 0.75) 4.

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Cases and figures

  • Case 1
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  • Case 2
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