Stevens Johnson syndrome

Dr Henry Knipe et al.

Stevens Johnson syndrome (SJS) is an acute inflammatory skin condition. 

Terminology

SJS is on a spectrum of disease with toxic epidermal necrolysis (TEN) at the more severe end. Terminology depending on how much surface area is involved 1,2:

  • SJS: <10%
  • SJS-TEN overlap: 10-30%
  • TEN: >30%

Epidemiology

SJS is very rare, with an incidence of 1-2 per 1,000,000 3

Pathology

SJS is thought to be triggered by preceding viral infection or more commonly medication use (e.g. NSAIDs, antibiotics, anticonvulsants). Skin and mucosal surface (e.g. gastrointestinal, genital, conjunctival) with blistering and shedding is characteristic 1-3.

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Article Information

rID: 42135
Section: Syndromes
Tags: skin, cases
Synonyms or Alternate Spellings:
  • Stevens-Johnson syndrome (SJS)

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