Stevens-Johnson syndrome

Last revised by Rohit Sharma on 21 Feb 2024

Stevens-Johnson syndrome (SJS) is an acute inflammatory skin condition, which is one of the drug-induced severe cutaneous adverse reactions (SCARs)

Stevens Johnson syndrome is on a spectrum of disease with toxic epidermal necrolysis syndrome (TENS) at the more severe end. Terminology depends on how much of the body surface area is involved 1,2:

  • SJS: <10%

  • SJS-TENS overlap: 10-30%

  • TENS: >30%

Stevens-Johnson syndrome is very rare, with an incidence of 1-2 per 1,000,000 3

The diagnosis of Stevens-Johnson syndrome is made clinically, few clinical features include:

  • fever

  • sore throat

  • runny nose

  • myalgia

  • painful rash with mucosal surface involvement

Stevens-Johnson syndrome is thought to be triggered by preceding viral infection or more commonly medication use (e.g. NSAIDs, antibiotics, antiseizure medications). Skin and mucosal surface (e.g. gastrointestinal, genital, conjunctival) with blistering and shedding are characteristic 1-3.

Differentials of Stevens-Johnson syndrome include:

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.