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Citation:
Gaillard F, Elfeky M, Gołofit P, Stipple sign (transitional cell carcinoma). Reference article, Radiopaedia.org (Accessed on 06 Oct 2024) https://radiopaedia.org/articles/2089
The stipple sign refers to the pointillistic end-on appearance on intravenous pyelography or retrograde pyelography of contrast material tracking into the interstices of a papillary lesion. Because the majority of transitional cell carcinomas (TCC) have a papillary configuration, the presence of this sign should raise the suspicion of TCC. While the stipple sign is best seen in large papillary bladder tumors, it can occur anywhere a urothelial tumor expresses papillary architecture.
Be aware, however, that the stipple sign may also be seen with blood clots and fungus balls, and is not pathognomonic for TCC.
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2. Ronan F. J. Browne, Conor P. Meehan, Jane Colville, Raymond Power, William C. Torreggiani. Transitional Cell Carcinoma of the Upper Urinary Tract: Spectrum of Imaging Findings1. (2005) RadioGraphics. doi:10.1148/rg.256045517
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3. McLean G, McLean PH, McLean BM, McLean. The "stipple sign" - urographic harbinger of transitional cell neoplasms. (1979) Urologic radiology. doi: - Pubmed
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