Stupp protocol for glioblastoma
The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) since its publication in 2005 and has lead to significant survival improvements 1. It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent.
According to the original study the Stupp protocol comprises:
- radiotherapy
- total 60 Gy
- 2 Gy per daily fraction (Monday to Friday) over 6 weeks
-
temozolomide
- during radiotherapy: 75 mg per square meter of body-surface area per day, 7 days per week
- post-radiotherapy (adjuvant): six cycles consisting of 150-200 mg per square meter for 5 days during each 28-day cycle
This therapy resulted in a significant survival improvement at 2 years:
- 26.5% 2-year-survival with Stupp protocol
- 10.4% 2-year-survival with radiotherapy alone
History and etymology
The Stupp protocol is named after Roger Stupp the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich 1.
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Astrocytic tumour
-
astrocytic tumours
- WHO classification of CNS tumours
- WHO grading of CNS tumours
- VASARI MRI feature set
- diffuse astrocytoma grading
- grade I:
- grade II:
- chordoid glioma of the third ventricle
-
low-grade diffuse astrocytoma
- fibrillary astrocytoma (no longer recognised)
- protoplasmic astrocytoma (no longer recognised)
- gemistocytic astrocytoma
- oligoastrocytoma
- pilomyxoid astrocytoma
- pleomorphic xanthoastrocytoma
- grade III
- grade IV:
-
glioblastoma (GBM)
- glioblastoma IDH wildtype
- glioblastoma IDH mutant
- glioblastoma NOS
- variants
- diffuse midline glioma H3 K27M–mutant
-
glioblastoma (GBM)
- glioblastoma vs cerebral metastasis
- radiation-induced gliomas
- gliomatosis cerebri (growth pattern)
- specific locations
- treatment response
- prognostic genetic markers
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