Stupp protocol for glioblastoma
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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Joshua Yap had no recorded disclosures.View Joshua Yap's current disclosures
The Stupp protocol has become the standard of care for the treatment of glioblastoma since its publication in 2005 and has led to significant survival improvements 1. It consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent.
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According to the original study, the Stupp protocol comprises:
total 60 Gy
2 Gy per daily fraction (Monday to Friday) over 6 weeks
during radiotherapy: 75 mg per square meter of body-surface area per day, 7 days per week
post-radiotherapy (adjuvant): 6 cycles consisting of 150-200 mg per square meter for 5 days during each 28-day cycle
This therapy resulted in a significant survival improvement at 2 years:
26.5% 2-year-survival with Stupp protocol
10.4% 2-year-survival with radiotherapy alone
A substantial minority of patients can demonstrate changes of pseudoprogression on follow-up imaging.
History and etymology
The Stupp protocol is named after Roger Stupp the first author of the 2005 paper, who is a Swiss oncologist from the University of Zürich 1.
- 1. Stupp R, Mason WP, van den Bent MJ et-al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 2005;352 (10): 987-96. doi:10.1056/NEJMoa043330 - Pubmed citation