Subacute lymphocytic thyroiditis or silent thyroiditis is a thyroid inflammatory condition, and a form of subacute thyroiditis.
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Clinical presentation
Usually characterised by the subacute onset of mild hyperthyroid symptoms, with an absence of thyroidal pain or tenderness, followed sometimes by hypothyroidism prior to recovery. On examination there can be a normal to moderately enlarged and firm thyroid gland.
Pathology
Histologically, the gland demonstrates lymphocytic infiltration, occasionally to the point of lymphoid follicle formation.
Associations
human leucocyte antigen (HLA) haplotypes, most often HLA-DR3
Markers
elevated levels of thyroid peroxidase (TPO) antibodies
elevated thyroglobulin antibodies
Radiographic features
Nuclear medicine
Thyroid scintigraphy typically shows markedly reduced radioiodine uptake and markedly decreased glandular activity 2.
Treatment and prognosis
The course is usually self-limiting. Moderate doses of beta blocking agents may provide symptomatic relief.
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